Overview Summary of Project
Naloxone is widely recommended for opioid overdose in humans, and is in many jurisdictions, including in the United States of America, distributed to police officers, social workers and laypeople for administration in such circumstances. There is a paucity of evidence regarding its use in cardiac arrest induced by opioid overdose, but such use is nonetheless generally recommended. Rat models, however, have been known for some time to show naloxone administration in asphyxia-induced cardiac arrest without opioid use having comparable benefit to the administration of epinephrine, and some recent evidence has suggested that naloxone in cardiac arrest may also be of benefit in humans, even where the arrest was not thought to be opioid-induced.
This study will employ a binary logistic regression model to investigate whether naloxone administration impacts rates of sustained ROSC and survival to hospital discharge, both in overdoses and in non-overdose arrests. It is a retrospective analysis of the Cardiac Arrest Registry to Enhance Survival (CARES) dataset, which is a national-level cardiac arrest registry in the United States of America with a catchment of over 186 million people and which has enrolled more than 1.3 million patients.
